The second season following the successful medical drama, Big White Duel II introduces two new characters. Nancy Wu will be getting heads on with Roger Kwok in the political stand for Marshall Paxton Hospital while involving in a love triangle between Kenneth Ma and Natalie Tong. Moses Chan is a new doctor joining the Emergency Unit and also ex-boyfriend of Kelly Cheng.
Dr. So / Zoe So Yee
Dr. Lee / Vincent Lee Man Shuen
Dr. Lui / Yan Lui Oi Ning
Dr. Yu / Samuel Yu Cham Tam
Dr. Wan / Martin Wan Ming Cheung
Cheung Ting
Dr. Ho / Hugo Ho Chi Gwong